The Bionas Discovery^TM 2500 system detects physiological parameters of living cells and tissue slices in a label-free and non-invasive assay. Cells are placed on a sensor chip and supplied with medium in a perfusion system. The multi-parametric sensor chip continuously measures:

Both parameters determine the acute rates of the cellular energy metabolism (bioenergetics).

• the cell impedance

This parameter detects alterations in the cellular adhesion/confluence and morphology

The perfusion system supplies the cells with nutrients and ensures a defined cell environmental condition throughout the whole experiment.

Long-term studies and regeneration
The perfusion system allows for parameter recordings over several days and enables the researcher:

• to monitor cellular responses to drug exposure in long-term studies
• to estimate recovery afterwards for the same cell population
• to collect information on adaptation effects after repeated drug exposure

The Bionas Discovery^TM adcon reader is a versatile system for real-time, label-free analysis of impedance/adhesion in convenient 96 well format. The impedance technology allows non-invasive monitoring of dynamic cellular events for screening applications and laboratory research. Effects on

• cell adhesion
• cell shape and volume
• cell-cell interactions
• cell viability
• cell number / proliferation
• cell morphology

are translated into digital time-resolved signals.


Applications for the Bionas Discovery^TM adcon reader are:

• receptor activation analysis, e.g. GPCR assays
• toxicity screening
• chemo-sensitivity of cancer cells
• drug discovery
• membrane integrity analysis
• cell culture optimization